In OS X there is this convenient 'Look Up in Dictionary' feature that works in Safari and other Apple applications. It can be invoked by right-clicking a selected word or a customizable keyboard shortcut (preset tois CMD-CTRL-D). Apple added a German dictionary (by Duden Verlag) only starting with OS X 10.8.
I'd also recommend extending the OS X dictionary by installing the dict.cc plugin for the OS X Dictionarydatabase from the German-English online dictionary dict.cc (not the browser toolbar!). The download includes the complete database (from 2011, I think), so it doesn't requireworks without an Internet connection. This dictionary plugin worksis compatible with OS X 10.5., 10.6 and 10.7 (probably also in 10.8). Download from http://www.dict.cc/?s=about%3Awordlist